Trimethylsilyl ((trimethylsilyl)oxy)acetate

Trimethylsilyl ((trimethylsilyl)oxy)acetate - Names and Identifiers

Name	Trimethylsilyl(trimethylsiloxy)acetate
Synonyms	Glycolic acid, di-TMS Glycolic acid, bis-TMS TRIMETHYLSILYL(TRIMETHYLSILOXY)ACETATE Trimethylsilyl(trimethylsiloxy)acetate trimethylsilyl(trimethylmethoxy)acetate TRIMETHYLSILYL (TRIMETHYLSILYLOXY)ACETATE Trimethylsilyl-[(trimethylsilyl)oxy]acetat Trimethylsilyl ((trimethylsilyl)oxy)acetate Trimethylsiloxyacetic acid trimethylsilyl ester Acetic acid, (trimethylsiloxy)-, trimethylsilyl ester
CAS	33581-77-0
EINECS	251-580-9
InChI	InChI=1/C8H20O3Si2/c1-12(2,3)10-7-8(9)11-13(4,5)6/h7H2,1-6H3

Trimethylsilyl ((trimethylsilyl)oxy)acetate - Physico-chemical Properties

Molecular Formula	C8H20O3Si2
Molar Mass	220.41
Density	0.903g/mLat 25°C(lit.)
Boling Point	82-83°C15mm Hg
Flash Point	110°F
Vapor Presure	1.09mmHg at 25°C
Specific Gravity	0.918
BRN	2045011
Storage Condition	Inert atmosphere,Room Temperature
Sensitive	7: reacts slowly with moisture/water
Refractive Index	n20/D 1.411(lit.)

Trimethylsilyl ((trimethylsilyl)oxy)acetate - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	UN 3272 3/PG 3
WGK Germany	2
FLUKA BRAND F CODES	21
TSCA	No
Hazard Class	3.2
Packing Group	III

Trimethylsilyl ((trimethylsilyl)oxy)acetate - Introduction

Trimethylsilyl(trimethylsiloxy)acetate, abbreviated as TMSA, is an organosilicon compound. The following is an introduction to the nature, use, formulation and safety information of TMSA:
Nature:
-Appearance: colorless liquid
-Solubility: Soluble in common organic solvents such as ethers, alcohols and esters
-Melting point:-80 ° C
-Boiling point: about 130 ° C
-Molecular formula: C9H22O4Si3
-Molecular weight: 262.53g/mol

Use:
- TMSA is commonly used as a reagent in organic synthesis, and can be used as an esterification agent, an acid catalyst and a protecting group in organic synthesis.
-In organic synthesis, TMSA can be used to synthesize alcohols, phenols and ether compounds.
-As a protecting group, TMSA can protect functional groups such as alcohols, phenols and ethers to prevent them from being changed or destroyed in chemical reactions.
- TMSA can also be used for the direct synthesis of ketones in organic synthesis.

Method:
The preparation of TMSA is usually carried out by the following steps:
1. Isopropyllithium (i-PrLi) is reacted with trimethylsilyl chloride (Me3SiCl) to produce trimethylsilyl lithium (Me3SiLi).
2. Trimethylsilanol acetate (Me3SiOAc) was obtained by reacting lithium trimethylsilane with acetic anhydride (Ac2O).
3. Reacting trimethylsilanol acetate with ethanol to obtain TMSA.

Safety Information:
- TMSA is generally stable and safe under normal operating and storage conditions.
-It is not flammable, but it can decompose when heated or in contact with oxygen to produce harmful gases.
-Avoid contact with skin and eyes when using TMSA, and ensure that it is operated in a well-ventilated place.
-Please handle and store the TMSA in accordance with proper laboratory practices and safety regulations.

Last Update：2024-04-10 22:29:15